A prospective study of maternal serum C‐reactive protein (CRP) concentrations and risk of gestational diabetes mellitus
- 13 September 2004
- journal article
- Published by Wiley in Paediatric and Perinatal Epidemiology
- Vol. 18 (5), 377-384
- https://doi.org/10.1111/j.1365-3016.2004.00578.x
Abstract
Low-grade systemic inflammation is associated with an increased risk of type 2 diabetes mellitus. Limited available data suggest inflammatory factors are predictive of gestational diabetes (GDM), a condition that is biochemically similar to type 2 diabetes. We examined the association between C-reactive protein (CRP) and GDM risk. Women were recruited before 16 weeks gestation and were followed until delivery. Maternal serum CRP (collected at 13 weeks’ gestation, on average) was measured by a competitive immunoassay. We used generalised linear models to derive estimates of relative risks and 95% confidence intervals [CI]. Approximately 4.5% of the cohort (38 of 851) developed GDM. Elevated CRP was positively associated with GDM risk (P for trend = 0.007). After adjusting for maternal prepregnancy body mass index (BMI), family history of type 2 diabetes and nulliparity, women with CRP in the highest tertile experienced a 3.5-fold increased risk of GDM [95% CI 1.2, 9.8] as compared with those in the lowest tertile. The association between CRP and GDM was evident when analyses were restricted to lean women (BMI < 25 kg/m2). Lean women with CRP ≥ 5.3 mg/L experienced a 3.7-fold increased risk of GDM [95% CI 1.6, 8.7] as compared with women with CRP < 5.3 mg/L. Systemic inflammation is associated with an increased risk of GDM, and the association is independent of maternal prepregnancy adiposity.Keywords
This publication has 31 references indexed in Scilit:
- C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular EventsCirculation, 2003
- Does Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. AdultsEpidemiology, 2002
- Gestational Diabetes MellitusNew England Journal of Medicine, 1999
- C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial DysfunctionArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- The role of TNFα in adipocyte metabolismSeminars in Cell & Developmental Biology, 1999
- TrueInternational Journal of Obesity, 1998
- Adipose tissue as an endocrine and paracrine organInternational Journal of Obesity, 1998
- Regulation of lipid metabolism by cytokines during host defenseNutrition, 1996
- Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
- Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6Hepatology, 1990