Ultrahigh-Field MR (7 T) Imaging of Brain Lesions in Neuromyelitis Optica
Open Access
- 27 January 2013
- journal article
- research article
- Published by Hindawi Limited in Multiple Sclerosis International
- Vol. 2013, 1-7
- https://doi.org/10.1155/2013/398259
Abstract
Background. Brain lesions are common in neuromyelitis optica spectrum disorder (NMOsd) and may resemble lesions of multiple sclerosis (MS).Objectives. To describe the imaging characteristics of supratentorial lesions in NMOsd on ultrahigh-field (7 T) MRI with special attention to vessel-lesion relationship.Methods. Ten NMOsd patients, all women and all seropositive for NMO IgG, with mean age of 51.3 ± 15.4 years and disease duration of 9.2 ± 6.4 years, were scanned at a 7 T whole-body human MR system with high-resolution 2D gradient echo sequence optimized to best visualize lesions and venous structures, T2- and T1-weighted imaging.Results. In 10 patients with NMOsd, a total of 92 lesions were observed (mean: 9.2 ± 8.8; range: 2–30), but only 8 lesions (9%) were traversed by a central venule. All lesions were Conclusions. Small, subcortical lesions without a central venule are the most consistent finding of NMOsd on 7 T MRI of the brain. Ultrahigh-field imaging may be useful for differentiating between NMOsd and MS.Keywords
This publication has 32 references indexed in Scilit:
- Do cortical lesions help us to distinguish MS from NMO?Neurology, 2012
- No MRI evidence of cortical lesions in neuromyelitis opticaNeurology, 2012
- Diffuse and heterogeneous T2-hyperintense lesions in the splenium are characteristic of neuromyelitis opticaMultiple Sclerosis Journal, 2012
- Serologic diagnosis of NMONeurology, 2012
- Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patientsJournal of Neuroinflammation, 2012
- Imaging Cortical Lesions in Multiple Sclerosis With Ultra–High-Field Magnetic Resonance ImagingArchives of Neurology, 2010
- Presence of a central vein within white matter lesions on susceptibility weighted imaging: a specific finding for multiple sclerosis?Neuroradiology, 2010
- Revised diagnostic criteria for neuromyelitis opticaNeurology, 2006
- Brain Abnormalities in Neuromyelitis OpticaArchives of Neurology, 2006
- White Matter Changes in Elderly People: MR-pathologic CorrelationsMagnetic Resonance in Medical Sciences, 2006