Changes of atherosclerosis of the carotid arteries due to severe Familial hypercholesterolemia following long-term plasmapheresis, assessed by duplex scan
- 1 February 1988
- journal article
- research article
- Published by Springer Science and Business Media LLC in Klinische Wochenschrift
- Vol. 66 (4), 149-152
- https://doi.org/10.1007/bf01727783
Abstract
Three males, aged 15, 22, and 25 years, have been followed for Familial hypercholesterolemia (FH) from 1968 and 1976 onward, being treated by plasmapheresis for 2 to 5 years continuously, at 1- to 2-week intervals. Whereas two patients have been continuously treated to date, the third discontinued plasma exchange after 4 years and has been reevaluated 6 years later. Discontinuation of plasma exchange led to progression of atherosclerosis of the carotid arteries documented by duplex scan, whereas one patient exhibited marked regression of former impressive soft plaque-formation and one patient showed no significant change. Two-dimensional computer-analysis suggested a reduction of plaque mass of up to 45% in one patient.Keywords
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