Video imaging of walking myosin V by high-speed atomic force microscopy
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Open Access
- 10 October 2010
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 468 (7320), 72-76
- https://doi.org/10.1038/nature09450
Abstract
High-speed atomic force microscopy can be used to record the structure and dynamics of biomolecules simultaneously. These authors use this method to directly observe the dynamics of the motor protein myosin V moving along actin filaments, with unprecedented time resolution. The high-resolution movies provide evidence supporting the 'swinging lever-arm' model of myosin motility, and provide important insights into the mechanism of motor movement.Keywords
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