Modes of action of lipid‐lowering diets in man: studies of apolipoprotein B kinetics in relation to fat consumption and dietary fatty acid composition
- 1 February 1983
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 13 (1), 79-85
- https://doi.org/10.1111/j.1365-2362.1983.tb00068.x
Abstract
The mechanisms by which dietary fat influences fasting plasma lipid concentrations were investigated in hyperlipidemic subjects. The synthetic and fractional catabolic (FCR) rates of the apoprotein B (apo B) of very-low density (VLDL) and low-density (LDL) lipoproteins were measured using radioiodinated autologous lipoproteins. Reductions of LDL concentration in 8 subjects during low-fat (25% of energy) diets were largely explained by diminished synthesis (-20%, P < 0.02), and possibly also by an increased FCR (+15%, P = 0.05) of LDL, compared with observations made during a high-fat (45% of energy) diet of similar fatty acid composition. VLDL apo B synthesis and FCR were not significantly altered. When a diet rich in polyunsaturated fatty acids was exchanged for one high in saturated fatty acids (fat providing 45% of energy on both occasions) in 4 subjects, the synthetic rates of both VLDL apo B (-31%, P < 0.02) and LDL apo B (-23%, P < 0.10) were reduced while their FCR were unchanged.Keywords
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