Pituitary Nuclear 3,5,3′-Triiodothyronine and Thyrotropin Secretion: An Explanation for the Effect of Thyroxine
- 11 November 1977
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4317), 617-620
- https://doi.org/10.1126/science.199941
Abstract
An excellent correlation was observed between nuclear triiodothyronine (T3) and the ensuing suppression of thyrotropin (TSH) after a single intravenous injection of T3 to thyroidectomized (hypothyroid) rats. At 1 and 2 hours after injection of thyroxine (T4), in amounts equally potent to the administered T3 in terms of acute suppression of TSH, the same quantities of T3 were found in the pituitary nuclei. Virtually no nuclear T4 was present, and plasma T3 was negligible at these short intervals after T4 injection. These results suggest that suppression of TSH release in hypothyroid rats occurs by interaction of T3 with the nuclear receptor of the thyrotroph. After T4 injection, the T3 found in the nucleus is derived from rapid intrapituitary monodeiodination.Keywords
This publication has 21 references indexed in Scilit:
- Isolation of labeled triiodothyronine from serum using affinity chromatography: Application to the estimation of the peripheral T4 to T3 conversion in ratsMetabolism, 1978
- Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated.JCI Insight, 1977
- Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process.Proceedings of the National Academy of Sciences of the United States of America, 1976
- Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated ratsMetabolism, 1975
- Thyroid Hormone Action in Cell Culture: Demonstration of Nuclear Receptors in Intact Cells and Isolated NucleiProceedings of the National Academy of Sciences of the United States of America, 1973
- Triiodothyronine and Thyroxine in the Serum and Thyroid Glands of Iodine-Deficient RatsJCI Insight, 1973
- Triiodothyronine: Review of recent studies of its physiology and pathophysiology in manMetabolism, 1972
- Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronineJCI Insight, 1972
- Specific Triiodothyronine Binding Sites in the Anterior Pituitary of the RatScience, 1972
- The effect of actinomycin-D on TSH formation, release and inhibition by thyroxinEuropean Journal of Pharmacology, 1968