Human Coronavirus OC43 Associated with Fatal Encephalitis
- 4 August 2016
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 375 (5), 497-498
- https://doi.org/10.1056/nejmc1509458
Abstract
Encephalitis is a serious neurologic syndrome characterized by brain inflammation that may be fatal. Although the majority of cases are caused by viruses, the identification of a causal organism can be difficult. Encephalopathy that affects patients with immunodeficiency is particularly challenging to diagnose, since the clinical presentation may be atypical and the differential diagnosis may include unusual pathogens or a noninfective cause. Deep sequencing of clinical samples has the potential to identify the pathogens associated with encephalitis, particularly in cases in which traditional techniques have not identified the candidate causative pathogen.1Keywords
This publication has 3 references indexed in Scilit:
- Bayesian mixture analysis for metagenomic community profilingBioinformatics, 2015
- Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised PatientsClinical Infectious Diseases, 2015
- Detection of Coronavirus in the Central Nervous System of a Child With Acute Disseminated EncephalomyelitisPEDIATRICS, 2004