Gender-dependent effects of selenite on the perfused rat heart
- 1 June 2007
- journal article
- Published by Springer Science and Business Media LLC in Biological Trace Element Research
- Vol. 116 (3), 301-309
- https://doi.org/10.1007/bf02698014
Abstract
Gender differences are related to the manner in which the heart responds to chronic and acute stress conditions of physiological and pathological nature. Depending on dose, sodium selenite acts as an antioxidant proven to have beneficial effects in several pathological conditions G. Drasch, J. Schopfer, and G. N. Schrauzer, Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and non-smokers, and relevance to the cancer protective effects of selenium,Biol. Trace Element Res. 103(2), 103–107 (2005); R. G. Kasseroller and G. N. Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review,Am. J. Ther. 7(4), 273–279 (2000); G. N. Schrauzer, Anticarcinogenic effects of selenium,Cell. Mol. Life Sci. 57(13–14), 1864–1873 (2000); I. S. Palmer and O. E. Olson, Relative toxicities of selenite and selenate in the drinking water of rats,J. Nutr. 104(3), 306–314 (1974). To date, little is known about the gender-dependent direct effects of toxic doses of selenite on electrophysiology of the cardiovascular system H. A. Schroeder and M. Mitchener, Selenium and tellurium in rats: effect on growth, survival and tumors,J. Nutr. 101(11), 1531–1540 (1971); G. N. Schrauzer, The nutritional significance, metabolism and toxicology of selenomethionine,Adv. Food Nutr. Res. 47, 73–112 (2003). In the present study, the effects of in vitro toxic concentrations of sodium selenite ranging from 10-6 M to 10-3 M were tested on both male and female rat heart preparations. The toxic effects seen in an electrocardiogram and left ventricular pressure were dose and sex dependent at most of the tested concentrations. The present study clearly shows that at toxic doses, stress conditions are induced by selenite, resulting in gender-dependent modifications of the heart function. This modification is more pronounced in the contraction cascade of female rats. Males, on the other hand, had been much more affected in excitation-related parameters.Keywords
This publication has 18 references indexed in Scilit:
- Gender differences in ANG II levels and action on multiple K+current modulation pathways in diabetic ratsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2004
- Assessment of requirements for selenium and adequacy of selenium status: a reviewEuropean Journal of Clinical Nutrition, 2004
- Sex differences in the modulation of K+ currents in diabetic rat cardiac myocytesThe Journal of Physiology, 2003
- Selenium, the Element of the Moon, in Life on EarthIUBMB Life, 2000
- SeleniumJournal of Toxicology: Clinical Toxicology, 1999
- Chemopreventive AgentsPharmacology & Therapeutics, 1998
- Age and gender differences in excitation‐contraction coupling of the rat ventricleThe Journal of Physiology, 1998
- 30-day oral toxicity study of -selenomethionine in female long-tailed macaques (Macaca fascicularis)Fundamental and Applied Toxicology, 1989
- Endemic selenium intoxication of humans in ChinaThe American Journal of Clinical Nutrition, 1983
- Toxicity of selenium to post-weanling ratsToxicology and Applied Pharmacology, 1966