The Oral Microbial Consortium's Interaction with the Periodontal Innate Defense System
- 1 August 2009
- journal article
- review article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 28 (8), 389-395
- https://doi.org/10.1089/dna.2009.0864
Abstract
The oral microbial consortium is the most characterized polymicrobial microbial community associated with the human host. Extensive sampling of both microbial and tissue samples has demonstrated that there is a strong association between the type of microbial community found in the gingival crevice and the status of innate host mediator expression. The strong clinical association between the microbial community and the innate host response in both clinically healthy and diseased tissue suggests that the oral consortium has a direct effect on periodontal tissue expression of innate defense mediators. A preliminary study in germ-free mice has demonstrated that the oral commensal consortium has direct effect on IL-1β expression, indicating that this microbial community may contribute to the strong protective status of healthy gingival tissue. Likewise, the lipopolysaccharide composition and invasion characteristics of Porphyromonas gingivalis, an oral bacterium strongly associated with periodontitis, suggest that it may be a keystone member of the oral microbial community and facilitate a destructive change in the protective gingival innate host status.Keywords
This publication has 102 references indexed in Scilit:
- Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity: differential activities of tetra- and penta-acylated lipid A structures on E-selectin expression and TLR4 recognitionCellular Microbiology, 2006
- Shield as Signal: Lipopolysaccharides and the Evolution of Immunity to Gram-Negative BacteriaPLoS Pathogens, 2006
- Quantitative Gene Expression Profiling Implicates Genes for Susceptibility and Resistance to Alveolar Bone LossInfection and Immunity, 2004
- Interactions between commensal intestinal bacteria and the immune systemNature Reviews Immunology, 2004
- Adhesion molecule expression in chronic inflammatory periodontal disease tissueJournal of Periodontal Research, 1994
- The immune system evolved to discriminate infectious nonself from noninfectious selfImmunology Today, 1992
- Influence of cigarette smoking on vascular reaction during experimental gingivitisEuropean Journal of Oral Sciences, 1988
- The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment lossJournal of Periodontal Research, 1986
- Effect of experimental neutropenia on initial gingivitis in dogsEuropean Journal of Oral Sciences, 1979
- The Passage of Tritiated Bacterial Endotoxin across Intact Gingival Crevicular EpitheliumThe Journal of Periodontology, 1972