Mitochondrial Complex I Deficiency in Parkinson's Disease
- 1 March 1990
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 54 (3), 823-827
- https://doi.org/10.1111/j.1471-4159.1990.tb02325.x
Abstract
The structure and function of mitochondrial respiratory-chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH-ubiquinone reductase (Complex I) and NADH cytochrome c reductase activities were significantly reduced, whereas succinate cytochrome c reductase activity was normal. These results indicated a specific defect of Complex I activity in the substantia nigra of patients with Parkinson's disease. This biochemical defect is the same as that produced in animal models of parkinsonism by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and adds further support to the proposition that Parkinson's disease may be due to an environmental toxin with action(s) similar to those of MPTP.This publication has 34 references indexed in Scilit:
- Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenoneFEBS Letters, 1987
- Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTPLife Sciences, 1986
- Role of metals in oxygen radical reactionsJournal of Free Radicals in Biology & Medicine, 1985
- Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineLife Sciences, 1985
- The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metalsBiochemical and Biophysical Research Communications, 1985
- Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTPBiochemical and Biophysical Research Communications, 1984
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences of the United States of America, 1979
- Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet lightJournal of Molecular Biology, 1975
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970