Insertion of a Pax6 Consensus Binding Site into the αA-Crystallin Promoter Acts as a Lens Epithelial Cell Enhancer in Transgenic Mice

Abstract

Purpose. Although the murine αA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene expression to the entire lens but not to the corneal epithelium.