Optical-resolution photoacoustic endomicroscopy in vivo
- 23 February 2015
- journal article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 6 (3), 918-32
- https://doi.org/10.1364/boe.6.000918
Abstract
Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.Keywords
Funding Information
- National Institutes of Health (NIH) (DP1 EB016986, P41-EB002182, R01 CA157277, R01 CA186567)
This publication has 46 references indexed in Scilit:
- Intravital analysis of vascular permeability in mice using two-photon microscopyScientific Reports, 2013
- Photoacoustic Tomography: In Vivo Imaging from Organelles to OrgansScience, 2012
- Biomedical photoacoustic imagingInterface Focus, 2011
- Intravital microscopy as a tool to study drug delivery in preclinical studiesAdvanced Drug Delivery Reviews, 2011
- Functional photoacoustic microscopy of pHJournal of Biomedical Optics, 2011
- Label-free oxygen-metabolic photoacoustic microscopy in vivoJournal of Biomedical Optics, 2011
- Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical ModelsMicrocirculation, 2010
- In vivo wide-area cellular imaging by side-view endomicroscopyNature Methods, 2010
- Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imagingNature Medicine, 2009
- Comprehensive volumetric optical microscopy in vivoNature Medicine, 2006