Fc receptors in antibody‐dependent enhancement of viral infections
Top Cited Papers
Open Access
- 26 October 2015
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 268 (1), 340-364
- https://doi.org/10.1111/imr.12367
Abstract
Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of viral pathogens, under certain conditions, antibodies provide an attractive means of enhanced virus entry and replication in a number of cell types. Known as antibody‐dependent enhancement (ADE) of infection, the phenomenon occurs when virus‐antibody immunocomplexes interact with cells bearing complement or Fc receptors, promoting internalization of the virus and increasing infection. Frequently associated with exacerbation of viral disease, ADE of infection presents a major obstacle to the prevention of viral disease by vaccination and is thought to be partly responsible for the adverse effects of novel antiviral therapeutics such as intravenous immunoglobulins. There is a growing body of work examining the intracellular signaling pathways and epitopes responsible for mediating ADE, with a view to aiding rational design of antiviral strategies. With in vitro studies also confirming ADE as a feature of infection for a growing number of viruses, challenges remain in understanding the multilayered molecular mechanisms of ADE and its effect on viral pathogenesis.Keywords
Funding Information
- National Institute of Allergy and Infectious Diseases (HHSN272201400006C)
- National Health and Medical Research Council (1030897, 512413)
This publication has 159 references indexed in Scilit:
- Immune Signaling by RIG-I-like ReceptorsImmunity, 2011
- Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexesThe Lancet Infectious Diseases, 2010
- The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing ActivityCell Host & Microbe, 2010
- Host response to influenza virus: protection versus immunopathologyCurrent Opinion in Immunology, 2010
- Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysisThe Lancet, 2010
- Enhanced Infection of Liver Sinusoidal Endothelial Cells in a Mouse Model of Antibody-Induced Severe Dengue DiseaseCell Host & Microbe, 2010
- Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibodyVirology, 2009
- TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritisNature Immunology, 2009
- Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptorProceedings of the National Academy of Sciences of the United States of America, 2008
- The Stoichiometry of Antibody-Mediated Neutralization and Enhancement of West Nile Virus InfectionCell Host & Microbe, 2007