Identification of new central nervous system specific mouse microRNAs
- 20 March 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (9), 2195-2200
- https://doi.org/10.1016/j.febslet.2006.03.019
Abstract
MicroRNAs (miRNAs) are small regulatory molecules suppressing mRNA activity in metazoans. Here we describe two new miRNAs cloned from brain tissue of mouse embryos. These miRNAs are expressed mainly during embryogenesis and specifically in the central nervous system. We also established the expression patterns of three recently identified miRNAs that were found in our short RNA library. All of them were expressed in the brain and spinal chord but while miR-410 and miR-431 were central nervous system specific, miR-500 was also expressed in limb buds. In addition, the expression of miR-500 in limb buds showed very strong asymmetry in favour of the left hand side.Keywords
This publication has 25 references indexed in Scilit:
- In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probesNature Methods, 2005
- Elucidation of the Small RNA Component of the TranscriptomeScience, 2005
- Identification of hundreds of conserved and nonconserved human microRNAsNature Genetics, 2005
- MicroRNA-Directed Cleavage of HOXB8 mRNAScience, 2004
- MicroRNAs: Genomics, Biogenesis, Mechanism, and FunctionCell, 2004
- Asymmetry in the Assembly of the RNAi Enzyme ComplexCell, 2003
- New microRNAs from mouse and humanRNA, 2003
- Identification of Novel Genes Coding for Small Expressed RNAsScience, 2001
- A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNAScience, 2001
- Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structureJournal of Molecular Biology, 1999