Dynamic changes in Japan’s prevalence of abnormal findings in cervical cytology depending on birth year
Open Access
- 4 April 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 8 (1), 1-4
- https://doi.org/10.1038/s41598-018-23947-6
Abstract
Japan’s governmental recommendation of HPV vaccine has now been suspended for more than 4 years. In and before 2013, the targets of 20-year-old cervical cancer screening were females born in and before 1993, i.e., those who could not have received HPV vaccination because it was not yet publicly introduced. The targets during 2014–2019 are, or will be, those born in 1994–1999, i.e., those who came of age during a period with the highest HPV immunization rate. We analyzed the statistical data for each birth year, for the cumulative HPV vaccination rates achieved as of age 16, and for the corresponding results of cervical cancer screening at age 20. The rate of abnormal findings in cervical cytology increased slightly from 3.68% in 2010 (birth year: 1990) to 4.35% in 2013 (birth year: 1993); however, it dynamically dropped to 2.99% in 2014 (birth year: 1994) and 3.03% in 2015 (birth year: 1995). In total, the rate of abnormal findings in cervical cytology was 3.96% in 2010–2013, but significantly dropped to 3.01% in 2014–2015 (p = 0.014). This is the first description of dynamic changes occurring in the abnormal rate of cervical cancer screening as a result of positive changes in national HPV vaccination rates.Keywords
This publication has 10 references indexed in Scilit:
- Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese womenJournal of Obstetrics and Gynaecology Research, 2017
- Early impact of the Japanese immunization program implemented before the HPV vaccination crisisInternational Journal of Cancer, 2017
- Outcomes for girls without HPV vaccination in JapanThe Lancet Oncology, 2016
- Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world ExperienceClinical Infectious Diseases, 2016
- HPV vaccine impact in Australian women: ready for an HPV‐based screening programThe Medical Journal of Australia, 2016
- Beneficial Effects of Human Papillomavirus Vaccine for Prevention of Cervical Abnormalities in Miyagi, JapanThe Tohoku Journal of Experimental Medicine, 2016
- Increasing trends in cervical cancer mortality among young Japanese women below the age of 50 years: An analysis using the kanagawa population-based cancer registry, 1975–2012Cancer Epidemiology, 2015
- HPV vaccination crisis in JapanThe Lancet, 2015
- Japan’s failure to vaccinate girls against human papillomavirusAmerican Journal of Obstetrics and Gynecology, 2015
- HPV vaccination programme in JapanThe Lancet, 2013