Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations

Abstract

A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TlNO₃) and a deoxygenation agent (Na₂SO₃). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml^–1 and a relative standard deviation of 3.74% at the 500 ng ml^–1 level. The method was applied to the analysis of pharmaceutical preparations.