Botulinum Neurotoxin Type A: Limited Proteolysis by Endoproteinase Glu-C and α-Chymotrypsin Enhanced Following Reduction; Identification of the Cleaved Sites and Fragments
- 1 October 1997
- journal article
- Published by Springer Science and Business Media LLC in Protein Journal
- Vol. 16 (7), 701-712
- https://doi.org/10.1023/a:1026358504860
Abstract
Botulinum neurotoxin (NT) serotype A is a ∼150-kDa dichain protein. Posttranslational nicking of the single-chain NT (residues Pro 1–Leu 1295) by the protease(s) endogenous to Clostridium botulinum...Keywords
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