Invasive Micropapillary Carcinoma of the Breast: An Immunohistochemical Study of Neoplastic and Stromal Cells
- 1 January 2005
- journal article
- case report
- Published by SAGE Publications in International Journal of Surgical Pathology
- Vol. 13 (1), 51-55
- https://doi.org/10.1177/106689690501300107
Abstract
A 59-year-old woman complained of a palpable mass in the right breast, and a needle biopsy disclosed small clusters of neoplastic cells in the fibrous stroma. The small clusters did not contain fibrovascular cores but exhibited micropapillary configuration. Epithelial membrane antigen (EMA) immunohistochemistry confirmed the reverse polarity of the neoplastic cells. Additionally, the plasma membrane of many neoplastic cells stained with E-cadherin and f-catenin. Myofibroblasts, which were positive for alpha smooth muscle actin (ASMA) and negative for cytokeratin 14, were abundant in the neoplastic stroma, but no CD34-positive stromal cells were observed in the neoplastic stroma. For comparison, 3 additional cases of invasive micropapillary carcinoma (IMC) and 4 cases of invasive ductal carcinoma (IDC) were studied. Similar results for stromal cells were obtained in all cases. Our results from this preliminary investigation suggest that CD34-positive stromal cells may disappear from the stroma of IMC as well as IDC.Keywords
This publication has 14 references indexed in Scilit:
- Invasive Micropapillary Carcinoma of the Breast: Are the Pure Forms More Aggressive than the Mixed Forms?The Breast Journal, 2003
- Smooth muscle cell differentiation in mammary stromo‐epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cellsHistopathology, 2003
- Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridizationHuman Pathology, 2002
- CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesionsVirchows Archiv, 2001
- Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast CarcinomaLaboratory Investigation, 2001
- Invasive micropapillary carcinoma of the breast: Eighty cases of an underrecognized entityHuman Pathology, 2001
- Importance of estrogen receptors for the behavior of invasive micropapillary carcinoma of the breast. Review of 68 cases with follow-up of 54Pathology - Research and Practice, 2000
- Invasive micropapillary carcinoma of the breast: A prognostic study*1Human Pathology, 1999
- Estrogen and Progesterone Receptors, C-ERBB-2, p53, and BCL-2 in Thirty-three Invasive Micropapillary Breast CarcinomasPathology - Research and Practice, 1996
- Invasive micropapillary carcinoma of the breast: A new special type of invasive mammary carcinomaPathology - Research and Practice, 1994