Platelet Rich Plasma and Knee Surgery
Open Access
- 2 September 2014
- journal article
- review article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2014, 1-10
- https://doi.org/10.1155/2014/890630
Abstract
In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon’s goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the field of regenerative medicine is witnessing a boost of autologous blood-derived platelet rich plasma products (PRPs) application to effectively mimic and accelerate the tissue healing process. The scientific rationale behind PRPs is the delivery of growth factors, cytokines, and adhesive proteins present in platelets and plasma, as well as other biologically active proteins conveyed by the plasma such as fibrinogen, prothrombin, and fibronectin; with this biological engineering approach, new perspectives in knee surgery were opened. This work describes the use of PRP to construct and repair every single anatomical structure involved in knee surgery, detailing the process conducted in ligament, meniscal, and chondral surgery.Keywords
This publication has 49 references indexed in Scilit:
- HGF Mediates the Anti-inflammatory Effects of PRP on Injured TendonsPLOS ONE, 2013
- Growth Factors and Stem Cells for the Management of Anterior Cruciate Ligament TearsThe Open Orthopaedics Journal, 2012
- Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic ChondrocytesThe American Journal of Sports Medicine, 2011
- Effects of age and platelet‐rich plasma on ACL cell viability and collagen gene expressionJournal of Orthopaedic Research, 2011
- Developmental Mechanisms in Articular Cartilage Degradation in OsteoarthritisArthritis, 2010
- Physiological loading of joints prevents cartilage degradation through CITED2The FASEB Journal, 2010
- Platelet-Rich Plasma Releasate Promotes Differentiation of Tendon Stem Cells into Active TenocytesThe American Journal of Sports Medicine, 2010
- Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repairBritish Journal of Sports Medicine, 2009
- Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approachesInternational Orthopaedics, 2007
- Yet more evidence that osteoarthritis is not a cartilage diseaseAnnals Of The Rheumatic Diseases, 2006