Nuclear Apoptosis Contributes to Sarcopenia
- 1 April 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Exercise and Sport Sciences Reviews
- Vol. 36 (2), 51-57
- https://doi.org/10.1097/jes.0b013e318168e9dc
Abstract
Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.Keywords
This publication has 30 references indexed in Scilit:
- Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophyAmerican Journal of Physiology-Cell Physiology, 2007
- Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonucleiAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2006
- Death receptor-associated pro-apoptotic signaling in aged skeletal muscleApoptosis, 2006
- Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosisExperimental Gerontology, 2006
- Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old ratsMuscle & Nerve, 2006
- Deficiency of the Bax gene attenuates denervation-induced apoptosisApoptosis, 2006
- Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged ratsJournal of Applied Physiology, 2006
- Molecular Regulation of Apoptosis in Fast Plantaris Muscles of Aged RatsThe Journals of Gerontology: Series A, 2006
- Exercise Training Attenuates Age-Induced Changes in Apoptotic Signaling in Rat Skeletal MuscleAntioxidants and Redox Signaling, 2006
- Aging alters the reduction of pro-apoptotic signaling in response to loading-induced hypertrophyExperimental Gerontology, 2006