Platelet-Rich Plasma: A Review of Biology and Applications in Plastic Surgery
Top Cited Papers
- 1 November 2006
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Plastic and Reconstructive Surgery
- Vol. 118 (6), 147e-159e
- https://doi.org/10.1097/01.prs.0000239606.92676.cf
Abstract
Learning Objectives: After studying this article, the reader should be able to: 1. Define the role of platelets in hemostasis and wound healing. 2. Describe the technologies for platelet concentration and application. 3. Characterize the platelet concentration and growth factor components of platelet-rich plasma. 4. List the potential applications of platelet-rich plasma in plastic surgery and how it may be applied intraoperatively. 5. Discuss the limitations of the use of platelet-rich plasma and its potential complications. Summary: Healing of hard and soft tissue is mediated by a complex array of intracellular and extracellular events that are regulated by signaling proteins, a process that is, at present, incompletely understood. What is certain, however, is that platelets play a prominent if not deciding role. Controlled animal studies of soft and hard tissues have suggested that the application of autogenous platelet-rich plasma can enhance wound healing. The clinical use of platelet-rich plasma for a wide variety of applications has been reported; however, many reports are anecdotal and few include controls to definitively determine the role of platelet-rich plasma. The authors describe platelet biology and its role in wound healing; the preparation, characterization, and use of platelet-rich plasma; and those applications in plastic surgery for which it may be useful.Keywords
This publication has 46 references indexed in Scilit:
- Platelet-rich plasma: evidence to support its useJournal of Oral and Maxillofacial Surgery, 2004
- Autologous platelets as a source of proteins for healing and tissue regenerationThrombosis and Haemostasis, 2004
- Prevention of postoperative bleeding in anticoagulated patients undergoing oral surgery: use of platelet-rich plasma gelJournal of Oral and Maxillofacial Surgery, 2003
- Do autologous growth factors enhance transforaminal lumbar interbody fusion?European Spine Journal, 2003
- Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healingExperimental and Molecular Pathology, 2003
- Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependentWound Repair and Regeneration, 2002
- Bone graft gel: Autologous growth factors used with autograft bone for lumbar spine fusionsAdvances in Therapy, 2002
- Mandibular reconstruction: A clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasmaInternational Journal of Oral & Maxillofacial Surgery, 2002
- Current Applications of Platelet Gels in Facial Plastic SurgeryFacial Plastic Surgery, 2002
- Alveolar Ridge and Sinus Augmentation Utilizing Platelet‐Rich Plasma in Combination With Freeze‐Dried Bone Allograft: Case SeriesThe Journal of Periodontology, 2000