High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming
Open Access
- 30 December 2020
- Vol. 13 (1), 89
- https://doi.org/10.3390/nu13010089
Abstract
Maternal diet is critical for offspring development and long-term health. Here we investigated the effects of a poor maternal diet pre-conception and during pregnancy on metabolic outcomes and the developing hypothalamus in male and female offspring at birth. We hypothesised that offspring born to dams fed a diet high in fat and sugar (HFSD) peri-pregnancy will have disrupted metabolic outcomes. We also determined if these HFSD-related effects could be reversed by a shift to a healthier diet post-conception, in particular to a diet high in omega-3 polyunsaturated fatty acids (ω3 PUFAs), since ω3 PUFAs are considered essential for normal neurodevelopment. Unexpectedly, our data show that there are minimal negative effects of maternal HFSD on newborn pups. On the other hand, consumption of an ω3-replete diet during pregnancy altered several developmental parameters. As such, pups born to high-ω3-fed dams weighed less for their length, had reduced circulating leptin, and also displayed sex-specific disruption in the expression of hypothalamic neuropeptides. Collectively, our study shows that maternal intake of a diet rich in ω3 PUFAs during pregnancy may be detrimental for some metabolic developmental outcomes in the offspring. These data indicate the importance of a balanced dietary intake in pregnancy and highlight the need for further research into the impact of maternal ω3 intake on offspring development and long-term health.Keywords
This publication has 82 references indexed in Scilit:
- A Western‐style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in miceThe Journal of Physiology, 2017
- Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markersAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2016
- Are Dietary Patterns of Mothers during Pregnancy Related to Childrens Weight Status? Evidence from the Lifeways Cross-Generational Cohort StudyAIMS Public Health, 2015
- Perinatal nutrition programs neuroimmune function long-term: mechanisms and implicationsFrontiers in Neuroscience, 2013
- Obesity: A Transgenerational Problem Linked to Nutrition during PregnancySeminars in Reproductive Medicine, 2012
- Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liverThe Journal of Nutritional Biochemistry, 2012
- Early life programming of obesity: the impact of the perinatal environment on the development of obesity and metabolic dysfunction in the offspring.Current Diabetes Reviews, 2012
- Influences on the quality of young children's diets: the importance of maternal food choicesBritish Journal of Nutrition, 2010
- Developmental origins of metabolic disease: life course and intergenerational perspectivesTrends in Endocrinology & Metabolism, 2010
- Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthoodAmerican Journal of Physiology-Endocrinology and Metabolism, 2006