Effects of Antibiotics on the Development of Asthma and Other Allergic Diseases in Children and Adolescents
Open Access
- 1 September 2018
- journal article
- research article
- Published by The Korean Academy of Asthma, Allergy and Clinical Immunology and The Korean Academy of Pediatric Al in Allergy, Asthma & Immunology Research
- Vol. 10 (5-6), 457-465
- https://doi.org/10.4168/aair.2018.10.5.457
Abstract
Purpose: Our aim was to explore whether antibiotic exposure in children and adolescents is associated with the later development of allergic diseases, using nationwide population-based claims data. Methods: We collected information from the National Health Insurance Service (2006-2015) database. A total of 5,626,328 children and adolescents were eligible for the study. We explored whether exposure to antibiotics over the prior 7 years affects the later development of allergic diseases. We ran 3 analytical models after adjusting for confounding factors including age, sex, the number of visits to healthcare providers, income, and the place of residence (urban/rural). Results: Allergic diseases were most common in male children and those aged < 10 years (atopic dermatitis, asthma and allergic rhinitis; all P < 0.01). Also, urban residents with higher incomes were more likely to develop allergic diseases (all P < 0.01). The annual number of days on which antibiotics were prescribed differed significantly between subjects with each allergic disease studied and a comparison group (all P < 0.01). Multiple logistic regression showed that as the duration of antibiotic exposure increased, the incidences of atopic dermatitis, asthma, and allergic rhinitis trended upward, even after adjusting for confounding factors (P for trend < 0.01). Conclusions: Antibiotic use early in life is associated with an increased risk of allergic disease, especially in young children; the risk increases as the duration of antibiotic therapy rises. Moreover, urban residence was more strongly associated with a longer duration of antibiotic use than was rural residence.Keywords
Funding Information
- Korean Society of Otorhinolaryngology-Head and Neck Surgery
This publication has 33 references indexed in Scilit:
- The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an updateClinical and Experimental Immunology, 2010
- The role of the intestinal microbiota in the development of atopic disordersAllergy, 2007
- Atopic dermatitis and the atopic marchJournal of Allergy and Clinical Immunology, 2003
- A Birth Cohort Study of Subjects at Risk of AtopyAmerican Journal of Respiratory and Critical Care Medicine, 2002
- The prevalence of atopic dermatitis in Oregon schoolchildrenJournal of the American Academy of Dermatology, 2000
- The intestinal microflora in allergic Estonian and Swedish 2‐year‐old childrenClinical and Experimental Allergy, 1999
- Early childhood infection and atopic disorderThorax, 1998
- The prevalence of childhood atopic eczema in a general populationJournal of the American Academy of Dermatology, 1994
- Hay fever, hygiene, and household size.BMJ, 1989