Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation
- 1 December 1980
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 288 (5791), 591-592
- https://doi.org/10.1038/288591a0
Abstract
The direct oncogenic potential of X rays has been demonstrated by the in vitro neoplastic transformation of mammalian cells in culture, a technique which permits the study of oncogenesis in the absence of host-specific effects. Although several agents are known to modulate in vitro neoplastic transformation by X rays, little is known of the effects of hormones. We now describe experiments which show that the presence of thyroid hormone is necessary for in vitro neoplastic transformation by X rays in cells of an established mouse fibroblast culture (C3H/10T1/2) and in early-passage diploid hamster embryo cells.This publication has 6 references indexed in Scilit:
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