Hug Tightly and Say Goodbye: Role of Endothelial ICAM-1 in Leukocyte Transmigration
- 1 April 2009
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 11 (4), 823-839
- https://doi.org/10.1089/ars.2008.2204
Abstract
Stable adhesion of leukocytes to endothelium is crucial for transendothelial migration (TEM) of leukocytes evoked during inflammatory responses, immune surveillance, and homing and mobilization of hematopoietic progenitor cells. The basis of stable adhesion involves expression of intercellular adhesion molecule-1 (ICAM-1), an inducible endothelial adhesive protein that serves as a counter-receptor for β2-integrins on leukocytes. Interaction of ICAM-1 with β2-integrins enables leukocytes to adhere firmly to the vascular endothelium and subsequently, to migrate across the endothelial barrier. The emerging paradigm is that ICAM-1, in addition to firmly capturing leukocytes, triggers intracellular signaling events that may contribute to active participation of the endothelium in facilitating the TEM of adherent leukocytes. The nature, duration, and intensity of ICAM-1-dependent signaling events may contribute to the determination of the route (paracellular vs. transcellular) of leukocyte passage; these aspects of ICAM-1 signaling may in turn be influenced by density and distribution of ICAM-1 on the endothelial cell surface, the source of endothelial cells it is present on, and the type of leukocytes with which it is engaged. This review summarizes our current understanding of the “ICAM-1 paradigm” of TEM with an emphasis on the signaling events mediating ICAM-1 expression and activated by ICAM-1 engagement in endothelial cells. Antioxid. Redox Signal. 11, 823–839.Keywords
This publication has 196 references indexed in Scilit:
- Activation of Syk by Protein Kinase C-δ Regulates Thrombin-induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells via Tyrosine Phosphorylation of RelA/p65Published by Elsevier BV ,2008
- Rosiglitazone attenuates NF-κB-dependent ICAM-1 and TNF-α production caused by homocysteine via inhibiting ERK1/2/p38MAPK activationBiochemical and Biophysical Research Communications, 2007
- RKIKK Motif in the Intracellular Domain Is Critical for Spatial and Dynamic Organization of ICAM-1: Functional Implication for the Leukocyte Adhesion and TransmigrationMolecular Biology of the Cell, 2007
- Thrombin, TNF-α, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cellsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2005
- Central involvement of Rho family GTPases in TNF-α-mediated bovine pulmonary endothelial cell apoptosisBiochemical and Biophysical Research Communications, 2003
- The Signaling Pathways Induced by Neutrophil-Endothelial Cell AdhesionAntioxidants and Redox Signaling, 2002
- Src Homology Domain 2-containing Tyrosine Phosphatase 2 Associates with Intercellular Adhesion Molecule 1 to Regulate Cell SurvivalPublished by Elsevier BV ,2000
- Cross-linking of Intercellular Adhesion Molecule-1 Induces Interleukin-8 and RANTES Production through the Activation of MAP Kinases in Human Vascular Endothelial CellsBiochemical and Biophysical Research Communications, 1998
- Activation of ICAM-1 promoter by lysophosphatidylcholine: Possible involvement of protein tyrosine kinasesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
- Protein kinase C inhibitors block the enhanced expression of Intercellular Adhesion Molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factorBiochemical and Biophysical Research Communications, 1990