The junctions that don’t fit the scheme: special symmetrical cell-cell junctions of their own kind
Open Access
- 14 August 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 338 (1), 1-17
- https://doi.org/10.1007/s00441-009-0849-z
Abstract
Immunocytochemical, electron-, and immunoelectron-microscopical studies have revealed that, in addition to the four major “textbook categories” of cell-cell junctions (gap junctions, tight junctions, adherens junctions, and desmosomes), a broad range of other junctions exists, such as the tiny puncta adhaerentia minima, the taproot junctions (manubria adhaerentia), the plakophilin-2-containing adherens junctions of mesenchymal or mesenchymally derived cell types including malignantly transformed cells, the composite junctions (areae compositae) of the mature mammalian myocardium, the cortex adhaerens of the eye lens, the interdesmosomal “sandwich” or “stud” junctions in the subapical layers of stratified epithelia and the tumors derived therefrom, and the complexus adhaerentes of the endothelial and virgultar cells of the lymph node sinus. On the basis of their sizes and shapes, other morphological criteria, and their specific molecular ensembles, these junctions and the genes that encode them cannot be subsumed under one of the major categories mentioned above but represent special structures in their own right, appear to serve special functions, and can give rise to specific pathological disorders.This publication has 106 references indexed in Scilit:
- Discovering the Molecular Components of Intercellular Junctions--A Historical ViewCold Spring Harbor Perspectives in Biology, 2009
- Characterization of the molecular phenotype of two arrhythmogenic right ventricular cardiomyopathy (ARVC)-related plakophilin-2 (PKP2) mutationsHeart Rhythm, 2008
- The desmosome and pemphigusHistochemistry and Cell Biology, 2008
- The art of cellular communication: tunneling nanotubes bridge the divideHistochemistry and Cell Biology, 2008
- Mechanisms of Disease: molecular genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathyNature Clinical Practice Cardiovascular Medicine, 2008
- A Novel Dominant Mutation in Plakoglobin Causes Arrhythmogenic Right Ventricular CardiomyopathyAmerican Journal of Human Genetics, 2007
- Functionally specialized junctions between endothelial cells of lymphatic vesselsThe Journal of Experimental Medicine, 2007
- Mutant Desmocollin-2 Causes Arrhythmogenic Right Ventricular CardiomyopathyAmerican Journal of Human Genetics, 2006
- Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Associated with Mutations in the Desmosomal Gene Desmocollin-2American Journal of Human Genetics, 2006
- DSG2 Mutations Contribute to Arrhythmogenic Right Ventricular Dysplasia/CardiomyopathyAmerican Journal of Human Genetics, 2006