The role of ATF‐2 in oncogenesis
- 17 March 2008
- Vol. 30 (4), 314-327
- https://doi.org/10.1002/bies.20734
Abstract
Activating Transcription Factor‐2 is a sequence‐specific DNA‐binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c‐jun, which are involved in oncogenesis in various tissue types. ATF‐2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF‐2. In this review, we summarize the signaling pathways that activate ATF‐2, as well as its downstream targets. We examine the role of ATF‐2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design. BioEssays 30:314–327, 2008.Keywords
This publication has 99 references indexed in Scilit:
- Brain Expressed microRNAs Implicated in Schizophrenia EtiologyPLOS ONE, 2007
- Reduced Levels of ATF-2 Predispose Mice to Mammary TumorsMolecular and Cellular Biology, 2007
- The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D3Cancer Research, 2006
- The Activation of c-Jun NH2-terminal Kinase (JNK) by DNA-damaging Agents Serves to Promote Drug Resistance via Activating Transcription Factor 2 (ATF2)-dependent Enhanced DNA RepairJournal of Biological Chemistry, 2003
- Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factorsGenes & Development, 2002
- Transendothelial Migration of Colon Carcinoma Cells Requires Expression of E-selectin by Endothelial Cells and Activation of Stress-activated Protein Kinase-2 (SAPK2/p38) in the Tumor CellsJournal of Biological Chemistry, 2001
- B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and FosOncogene, 2000
- The Hallmarks of CancerCell, 2000
- ATF2 confers radiation resistance to human melanoma cellsOncogene, 1998
- Assignment of the human CREB2 (CRE-BP1) gene to 2q32Genomics, 1991