Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin
- 1 September 1982
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 299 (5879), 126-131
- https://doi.org/10.1038/299126a0
Abstract
An immunoreactive analog of [human] erythrocyte spectrin was purified from brain membranes. This protein cosedimented with and cross-linked actin filaments, associated with spectrin-binding sites on erythrocyte membranes, and was visualized by rotary shadowing as an extended, flexible rod. The brain spectrin comprises 3% of the total membrane protein and may have a major role in mediating linkage of actin to membranes.Keywords
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