Gastric and Prostate Adenocarcinoma in a Patient with Metastatic Gastrointestinal Stromal Tumor
- 5 October 2007
- journal article
- case report
- Published by S. Karger AG in Oncology Research and Treatment
- Vol. 30 (11), 568-570
- https://doi.org/10.1159/000108640
Abstract
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of the gastrointestinal tract. Gastric cancer is the second most common neoplasm worldwide. Prostate cancer is the most common non-cutaneous cancer. The most frequently encountered second malignancies in patients with prostate adenocarcinoma include carcinomas of the bladder, stomach, and colon, followed by cutaneous and hematolymphoid malignancies. We report the case of a 60-year-old male patient who was diagnosed with GIST and started on imatinib mesylate 400 mg/day. 2 years later, the patient was diagnosed with gastric adenocarcinoma, and a subtotal gastrectomy and gastrojejunostomy were performed. At followup 6 months later, prostate-specific antigen (PSA) levels were elevated, and a prostate biopsy showed a prostate adenocarcinoma. This is the second report of metachronous prostate cancer, gastric cancer, and GIST in the English language literature.Keywords
This publication has 11 references indexed in Scilit:
- Occurrence of other malignancies in patients with gastrointestinal stromal tumorsSeminars in Diagnostic Pathology, 2006
- Hämorrhagischer Schock bei Doppelmalignom: Gastrointestinaler Stromatumor (GIST) und neuroendokrines Karzinom bei Morbus RecklinghausenZeitschrift für Gastroenterologie, 2005
- PDGFRA Activating Mutations in Gastrointestinal Stromal TumorsScience, 2003
- Collision Tumor of the StomachJournal of Clinical Gastroenterology, 2002
- Associated Primary Tumors in Patients With Gastric CancerJournal of Clinical Gastroenterology, 2002
- Risk of multiple primary cancers in prostate cancer patients in the Detroit metropolitan area: A retrospective cohort studyThe Prostate, 1997
- Synchronous and metachronous primary gastric lymphoma and adenocarcinomaCancer, 1997
- Multiple Primary Malignant Neoplasms Associated with Prostate Cancer in 312 Consecutive CasesUrologia Internationalis, 1997
- Neuroectodermal Differentiation of the Gastrointestinal Tumors in the Carney TriadThe American Journal of Surgical Pathology, 1993
- Multiple primary malignant neoplasms.I. Introduction and presentation of dataCancer, 1961