The performance of several graphical (zero-crossing and derivative quotient spectra with standardized divisor) and numerical methods (MULTIC and PLS) for the resolution of binary and ternary mixtures of species is compared. Numerical methods were found to be specially suited to multicomponent analysis, particularly for mixtures containing more than two analytes with highly overlapped spectra. The results obtained by using the compared methods to analyse various synthetic mixtures of acetylsalicylic acid, caffeine and thiamine were quite consistent and errors in the simultaneous quantification of the analytes amounted to less than 5% in all instances.