Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding
Top Cited Papers
- 21 May 2010
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 328 (5981), 1036-1040
- https://doi.org/10.1126/science.1186176
Abstract
Subtle Variation: Despite vast phenotypic differences, vertebrates have many readily recognizable specific cell types, like liver hepatocytes. The gene expression that defines specific cells depends on evolutionarily conserved orthologous transcription factors. Schmidt et al. (p. 1036 , published online 8 April) studied the conservation and divergence in the genome-wide binding of two such transcription factors, CEBPA and HNF4A, in livers from human, dog, mouse, short-tailed opossum, and chicken. Although the sequence bound by orthologous transcription factors was similar, the vast majority of binding events were unique to each species.This publication has 29 references indexed in Scilit:
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