Deregulated c-fos expression interferes with normal bone development in transgenic mice
- 1 January 1987
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 325 (6103), 412-416
- https://doi.org/10.1038/325412a0
Abstract
Transgenic mice were generated expressing c-fos genes under the control of the human metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interfered with normal bone development without inducing malignant tumours.Keywords
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