Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals
- 19 February 2019
- journal article
- research article
- Published by Elsevier BV in Cell Host & Microbe
- Vol. 25 (3), 357-366.e6
- https://doi.org/10.1016/j.chom.2019.01.002
Abstract
No abstract availableKeywords
Funding Information
- National Institute of Allergy and Infectious Disease (U19AI082724, P01AI097092, U19AI109946, U19AI057266, HHSN272201400005C, AI057229, R01 AI117287, HHSN272201400008C, 1R01AI113047, 1R01AI108686, HHSN272201400005C, DP2AI117921, HHSN272201400005C, UL1TR002001, HHSN272201400005C)
- NIA
- Duke Pepper Older Americans Independence Center (P30AG028716)
This publication has 40 references indexed in Scilit:
- Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in HumansmBio, 2016
- Effect of Previous-Year Vaccination on the Efficacy, Immunogenicity, and Safety of High-Dose Inactivated Influenza Vaccine in Older AdultsClinical Infectious Diseases, 2016
- Lineage Structure of the Human Antibody Repertoire in Response to Influenza VaccinationScience Translational Medicine, 2013
- Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cellsProceedings of the National Academy of Sciences of the United States of America, 2012
- Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodiesJCI Insight, 2011
- Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infectionThe Journal of Experimental Medicine, 2011
- Vaccination in the elderly: an immunological perspectiveTrends in Immunology, 2009
- Impact of age on hypermutation of immunoglobulin variable genes in humans.Journal of Clinical Immunology, 2001
- Community‐Acquired Pneumonia in the ElderlyClinical Infectious Diseases, 2000
- Age‐related alterations of somatic hypermutation and CDR3 lengths in human Vκ4‐expressing B lymphocytesImmunology, 1999