Positional signalling and specification of digits in chick limb morphogenesis
- 1 March 1975
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 254 (5497), 199-202
- https://doi.org/10.1038/254199a0
Abstract
The interpretation of positional information can provide the basis for pattern formation in limb morphogenesis. The gradient in positional information along the antero-posterior axis, which is specified with respect to a localised boundary region, can be modified by grafting this region to successive positions along the axis. The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.Keywords
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