Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.
Open Access
- 1 January 1987
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 79 (1), 48-51
- https://doi.org/10.1172/jci112806
Abstract
Monokine-stimulated endothelial cells are known to produce both burst- and colony-stimulating activities, but neither the nature of the monokine nor the hematopoietic growth factor(s) produced is known. We show by mRNA analysis that an immortalized line of human endothelial cells constitutively produce granulocyte-macrophage colony-stimulating factor. Furthermore, interleukin 1 and tumor necrosis factor induce early passage human umbilical endothelial cells to produce the same growth factor.Keywords
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