The Biosynthesis of Collagen and Its Disorders
- 5 July 1979
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 301 (1), 13-23
- https://doi.org/10.1056/nejm197907053010104
Abstract
(First of Two Parts)COLLAGEN is the major macromolecule of most connective tissues, and it is widely believed that many human diseases, particularly chronic diseases, will be found to involve this protein either directly or indirectly. Since collagen biosynthesis was last reviewed in the Journal in 1972,1 much new information has been gained about the relatively complex pathway by which it is synthesized. We should like to consider this new information and some of its consequences in terms of the following questions:What is the structural information in the collagen molecule, and how does it determine the structure of the . . .Keywords
This publication has 102 references indexed in Scilit:
- Translation of chick calvarial procollagen messenger RNAs by a messenger RNA dependent reticulocyte lysateBiochemistry, 1978
- Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagenBiochemistry, 1978
- Three new α-chains of collagen from a non-basement membrane sourceBiochemical and Biophysical Research Communications, 1978
- Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyprolineBiochemical and Biophysical Research Communications, 1977
- Molecular packing of collagen: Three-dimensional analysis of electrostatic interactionsJournal of Molecular Biology, 1976
- Affinity Chromatography of Collagen Glycosyltransferases on Collagen Linked to AgaroseEuropean Journal of Biochemistry, 1976
- Intracellular Aspects of the Process of Protein SynthesisScience, 1975
- The intracellular location of the glycosylation of hydroxylysine of collagenBiochemical and Biophysical Research Communications, 1975
- Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bonsBiochemical and Biophysical Research Communications, 1973
- The stability of collagen cross-links when derived from hydroxylysyl residuesBiochemical and Biophysical Research Communications, 1973