Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21
- 1 May 2008
- journal article
- letter
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 39 (5), 1586-1589
- https://doi.org/10.1161/STROKEAHA.107.502963
Abstract
Background and Purpose— Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes. Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic stroke in our population. Methods— We recently initiated a whole genome analysis of ischemic stroke and published the first stage of a case control study using >400 000 SNPs from Illumina Infinium Human-1 and HumanHap300 assays. We focused on SNPs recently associated with heart disease by Helgadottir and colleagues and SNPs from the same haplotype block. Results— In analyses both unadjusted and adjusted for stroke risk factors, significant associations with ischemic stroke were observed for SNPs from the same haplotype block previously associated with myocardial infarction. Significant association was also seen between disease and haplotypes involving these SNPs, both with and without adjustment for stroke risk factors (odd ratios: 1.01 to 2.65). Conclusions— These data are important for 3 reasons: first, they suggest a genetic association for stroke; second, they suggest that this association shares pathogenic mechanisms with heart disease and diabetes; and third, they illustrate, that public release of data can facilitate rapid risk locus discovery.This publication has 13 references indexed in Scilit:
- Two Common Gene Variants on Chromosome 9 and Risk of AtherothrombosisStroke, 2007
- Genomewide Association Analysis of Coronary Artery DiseaseThe New England Journal of Medicine, 2007
- A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial InfarctionScience, 2007
- A Common Allele on Chromosome 9 Associated with Coronary Heart DiseaseScience, 2007
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 DiabetesScience, 2007
- A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility VariantsScience, 2007
- A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data releaseThe Lancet Neurology, 2007
- Effects of Splinting on Wrist Contracture After StrokeStroke, 2007
- The Regulation of INK4/ARF in Cancer and AgingCell, 2006