Risk assessments of polychlorinated dibenzo‐ p‐dioxins, polychlorinated dibenzofurans, and dioxin‐like polychlorinated biphenyls in food
- 28 September 2006
- journal article
- review article
- Published by Wiley in Molecular Nutrition & Food Research
- Vol. 50 (10), 885-896
- https://doi.org/10.1002/mnfr.200500247
Abstract
The polychlorinated dibenzo‐p‐dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and dioxin‐like polychlorinated biphenyls (dioxin‐like PCB) are ubiquitous in food of animal origin and accumulate in fatty tissues of animals and humans. The most toxic congener is 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD). The toxic responses include dermal toxicity, immunotoxicity, carcinogenicity, and reproductive and developmental toxicity. Toxic equivalency factors have been established for the other PCDD, PCDF and dioxin‐like PCB relative to TCDD, and the combined toxicity of a sample can be expressed as toxic equivalent (WHO‐TEQ). The EC Scientific Committee for Food evaluated these compounds in 2001. The assessment used the most sensitive adverse toxicological end‐points of TCDD in experimental animals. These were developmental and reproductive effects in the male offspring of rats administered TCDD during pregnancy. Because of the large difference between rats and humans in the biological half‐life of TCDD, the assessment used a body burden approach to compare across species and derived a tolerable weekly intake of 14 pg TCDD/kg of body weight (bw), which was extended to include all the 2,3,7,8‐substituted PCDD and PCDF, and the dioxin‐like PCB, and expressed as a group tolerable weekly intake of 14 pg WHO‐TEQ/kg bw. The FAO/WHO Joint Expert Committee on Food Additives (JECFA) performed a similar assessment whereas the US Environmental Protection Agency (US EPA) has paid more attention to human data on carcinogenicity.Keywords
This publication has 32 references indexed in Scilit:
- PCB-related neurodevelopmental deficit may be transient: follow-up of a cohort at 6 years of ageEnvironmental Toxicology and Pharmacology, 2005
- Dose-Additive Carcinogenicity of a Defined Mixture of “Dioxin-like Compounds”Environmental Health Perspectives, 2005
- Maternal Exposure to a Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats: Dose-Dependent Increase of mRNA Levels of 5 -Reductase Type 2 in Contrast to Decrease of Androgen Receptor in the Pubertal Ventral ProstateToxicological Sciences, 2001
- Consultation on assessment of the health risk of dioxins; re-evaluation of the tolerable daily intake (TDI): Executive SummaryFood Additives & Contaminants, 2000
- Dose–Response Relationships for Polyhalogenated Dioxins and Dibenzofurans Following Subchronic Treatment in MiceToxicology and Applied Pharmacology, 1997
- In UteroExposure to Low Doses of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters Reproductive Development of Female Long Evans Hooded Rat OffspringToxicology and Applied Pharmacology, 1997
- Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin II. Effects on the pup and the adultToxicology, 1997
- A Dose–Response Analysis of the Reproductive Effects of a Single Gestational Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Male Long Evans Hooded Rat OffspringToxicology and Applied Pharmacology, 1997
- Dose-Response Relationships in Mice Following Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, Estrogen Receptor, and Protein Tyrosine PhosphorylationToxicology and Applied Pharmacology, 1994
- The Toxicokinetics and Metabolism of Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Dibenzofurans (PCDFs) and Their Relevance for ToxicityCritical Reviews in Toxicology, 1994