Experimental tinea pedis induced by non-abrasive inoculation ofTrichophyton mentagrophytesarthrospores on the plantar part of a guinea pig foot
- 1 January 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 25 (4), 203-213
- https://doi.org/10.1080/02681218780000541
Abstract
Arthrospores of Trichophyton mentagrophytes were inoculated on to the plantar part of a guinea pig foot by a newly devised non-abrasive method. Anthropophilic and zoophilic isolates required inocula of 280 and 80 arthrospores to infect 50% of inoculated feet, but much larger inocula (5 X 10(4)) were used to establish infection consistently in all feet. Anthropophilic isolate NTM-105 invaded only the upper two-thirds of the horny layer and induced no inflammatory responses. On the other hand, zoophilic isolate SM-110 invaded the whole horny layer and provoked strong inflammatory responses and clinical manifestations. Although the histological features and modes of fungal spreading in the guinea pig skin were quite different between anthropophilic and zoophilic isolate infections, infecting fungi were always recognized in the stratum corneum of all inoculated feet throughout the observation period longer than 6 months. Thus, two types of persistent infections with T. mentagrophytes were established as a guinea pig model of tinea pedis.Keywords
This publication has 12 references indexed in Scilit:
- A simple and reliable culturing method for production of arthrospores by dermatophytes.Japanese Journal of Medical Mycology, 1986
- The Production of Experimental Dermatophyte Lesions in Guinea PigsJournal of Investigative Dermatology, 1979
- A Quantitative Dermatophyte Infection Model In The Guinea-Pig—A Parallel To The Quantitated Human Infection ModelJournal of Investigative Dermatology, 1976
- Trichophytin Contact Sensitivity in Guinea Pigs with Experimental Dermatophytosis Induced by A New Inoculation MethodJournal of Investigative Dermatology, 1973
- Experimental production of tinea pedisJournal of the American Podiatric Medical Association, 1967
- An Experimental Study of Tinea Pedis and Onychomycosis of the FootArchives of Dermatology, 1957
- Survival of Dermatophytes Applied on the FeetJournal of Investigative Dermatology, 1955
- SKIN DISEASE IN THE BRITISH ARMY IN S.E. ASIA.*.British Journal of Dermatology, 1953
- Beitrag zur kollektiven Behandlung pharmakologischer ReihenversucheNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1931
- Zur Lehre von den DermatomykosenArchiv für dermatologische Forschung, 1908