MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression
Open Access
- 13 May 2013
- journal article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 34 (9), 2071-2079
- https://doi.org/10.1093/carcin/bgt160
Abstract
The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impact of NDRG1 on cancer metastasis with emphasis on its interactions with the key oncogenic nuclear factor-kappaB, phosphatidylinositol-3 kinase/phosphorylated AKT/mammalian target of rapamycin and Ras/Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways. Recent studies demonstrating the inhibitory effects of NDRG1 on the epithelial–mesenchymal transition, a key initial step in metastasis, TGF-β pathway and the Wnt/β-catenin pathway are also described. Furthermore, NDRG1 was also demonstrated to regulate molecular motors in cancer cells, leading to inhibition of F-actin polymerization, stress fiber formation and subsequent reduction of cancer cell migration. Collectively, this review summarizes the underlying molecular mechanisms of the antimetastatic effects of NDRG1 in cancer cells.Keywords
This publication has 31 references indexed in Scilit:
- Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasisNature Communications, 2011
- Endothelial progenitor cell biology in disease and tissue regenerationJournal of Hematology & Oncology, 2011
- The clinical potential of microRNAsJournal of Hematology & Oncology, 2010
- AngiomiRs—Key regulators of angiogenesisCurrent Opinion in Genetics & Development, 2009
- miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial CellsCancer Cell, 2008
- Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesisProceedings of the National Academy of Sciences of the United States of America, 2008
- Tumor AngiogenesisNew England Journal of Medicine, 2008
- Role of Dicer and Drosha for Endothelial MicroRNA Expression and AngiogenesisCirculation Research, 2007
- Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial CellsCirculation Research, 2007
- MicroRNA Signatures in Human CancersNature Reviews Cancer, 2006