The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Top Cited Papers
- 29 May 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 368 (6494), 973-980
- https://doi.org/10.1126/science.aay9189
Abstract
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients’ smoking status, and the response to immunotherapy.Keywords
Funding Information
- National Institutes of Health (1R01CA219896-01A1)
- American Association for Cancer Research (SU2C-AACR-IRG-19-17)
- Israel Cancer Research Fund
- H2020 European Research Council (818086)
- United States-Israel Binational Science Foundation (2013332)
- United States-Israel Binational Science Foundation (2013332)
- Israel Ministry of Science, Technology & Space (3-11174)
- Israel Science Foundation (2044/17)
- Rising Tide Foundation
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