Simultaneous Determination of 7 N-Acetyltransferase-2 Single-Nucleotide Variations by Allele-Specific Primer Extension Assay
Open Access
- 1 June 2006
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 52 (6), 1033-1039
- https://doi.org/10.1373/clinchem.2005.063198
Abstract
Background: Genotyping of N-acetyltransferase-2 (NAT2) is useful in predicting the risk for toxicity of NAT2 substrates. Current methods cannot detect the 7 most important single-nucleotide variations in NAT2 simultaneously in 1 tube.Keywords
This publication has 30 references indexed in Scilit:
- N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer riskOncogene, 2006
- Arylamine N‐acetyltransferase‐2 genotypes in the Thai populationBritish Journal of Clinical Pharmacology, 2003
- Polymorphism of theN-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitisJournal of Hepatology, 2002
- N-Acetyltransferase2 Genotype Correlated with Isoniazid Acetylation in Japanese Tuberculous Patients.Biological & Pharmaceutical Bulletin, 2001
- Lung cancer and mutations at the polymorphic NAT2 gene locusPharmacogenetics, 1995
- Effect of cooking temperature on the formation of heterocyclic amines in fried meat products and pan residuesCarcinogenesis: Integrative Cancer Research, 1995
- Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) genePharmacogenetics, 1994
- SHORT COMMUNICATION: Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-AmericansCarcinogenesis: Integrative Cancer Research, 1993
- Human ArylamineN-Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional ExpressionDNA and Cell Biology, 1990
- ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCERThe Lancet, 1982