Comparison of Metformin and Repaglinide Monotherapy in the Treatment of New Onset Type 2 Diabetes Mellitus in China
Open Access
- 1 January 2014
- journal article
- research article
- Published by Hindawi Limited in Journal of Diabetes Research
- Vol. 2014, 1-6
- https://doi.org/10.1155/2014/294017
Abstract
Objective. This study was designed to compare the effects of metformin and repaglinide on the fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c) in newly diagnosed type 2 diabetes in China.Methods. A total of 107 newly diagnosed type 2 diabetic patients (46 women and 61 men) participated in the study. All patients received 3-month treatment of metformin or repaglinide. Fasting blood glucose and HbA1c were determined at baseline and at the end of the 3-month of treatment.Results. FPG and HbA1c decreased in both metformin and repaglinide groups after 3 months treatment (. The reduction of HbA1c was significantly greater in the repaglinide group. Metformin decreases fasting insulin concentration and HOMA-IR, and repaglinide improves HOMA-. Triglycerides (TG) were reduced in both groupsin metformin group;in repaglinide group), but total cholesterol (TC) and low-density lipoprotein (LDL) were decreased only after metformin treatment.Conclusions. Both repaglinide and metformin were effective in glycaemic control in new onset patients with type 2 diabetes in China. Repaglinide had no effect on insulin sensitivity, but it improved-cell function.
Keywords
Funding Information
- National Natural Science Foundation of China (81070651)
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