Retinoic acid in the development, regeneration and maintenance of the nervous system
Top Cited Papers
- 1 October 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 8 (10), 755-765
- https://doi.org/10.1038/nrn2212
Abstract
Retinoic acid (RA) is involved in the induction of neural differentiation, motor axon outgrowth and neural patterning. Like other developmental molecules, RA continues to play a role after development has been completed. Elevated RA signalling in the adult triggers axon outgrowth and, consequently, nerve regeneration. RA is also involved in the maintenance of the differentiated state of adult neurons, and disruption of RA signalling in the adult leads to the degeneration of motor neurons (motor neuron disease), the development of Alzheimer's disease and, possibly, the development of Parkinson's disease. The data described here strongly suggest that RA could be used as a therapeutic molecule for the induction of axon regeneration and the treatment of neurodegeneration.Keywords
This publication has 101 references indexed in Scilit:
- Lin−CD34− bone marrow cells from adult mice can differentiate into neural-like cellsNeuroscience Letters, 2006
- Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neuronsDevelopmental Biology, 2006
- Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's diseaseExperimental Neurology, 2004
- Presenilin 2 Expression in Neuronal Cells: Induction during Differentiation of Embryonic Carcinoma CellsExperimental Cell Research, 2000
- Regulation of Acetylcholinesterase Expression during Neuronal DifferentiationOnline Journal of Public Health Informatics, 1996
- Coordinated Up-regulation of Choline Acetyltransferase and Vesicular Acetylcholine Transporter Gene Expression by the Retinoic Acid Receptor α, cAMP, and Leukemia Inhibitory Factor/Ciliary Neurotrophic Factor Signaling Pathways in a Murine Septal Cell LineOnline Journal of Public Health Informatics, 1995
- All‐trans‐ and 9‐cis‐Retinoic Acid Enhance the Cholinergic Properties of a Murine Septal Cell Line: Evidence that the Effects Are Mediated by Activation of Retinoic Acid Receptor‐αJournal of Neurochemistry, 1995
- Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell lineExperimental Cell Research, 1984
- Cell proliferation and DNA replication in the imaginal wing disc of Drosophila melanogasterDevelopmental Biology, 1984
- Induction of neural-like cells and acetylcholinesterase activity in cultures of F9 teratocarcinoma treated with retinoic acid and dibutyryl cyclic adenosine monophosphateDevelopmental Biology, 1980