5-HT and the brain–gut axis: opportunities for pharmacologic intervention
- 15 May 2007
- journal article
- Published by Informa Healthcare in Expert Opinion on Investigational Drugs
- Vol. 16 (6), 761-765
- https://doi.org/10.1517/13543784.16.6.761
Abstract
Interactions between the enteric nervous system of the gut and the brain occur bidirectionally over sympathetic and parasympathetic pathways. Coordinated actions of the central, autonomic and enteric nervous systems modulate intestinal motor, sensory and secretory activities by neuromodulators, including 5-HT, noradrenaline and dopamine. 5-HT is an important signaling molecule in the brain-gut axis and the 5-HT released from enterochromaffin cells modulates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. Irritable bowel syndrome is associated with altered motility, secretion and sensation; enteric 5-HT signaling may be defective in this disorder. In this editorial, recent data are reviewed and the potential for the development of pharmacologic intervention is assessed.Keywords
This publication has 33 references indexed in Scilit:
- Functional bowel disorders and functional abdominal painGut, 1999
- Impact of Irritable Bowel Syndrome on Quality of Life and Resource Use in the United States and United KingdomDigestion, 1999
- Altered rectal perception is a biological marker of patients with irritable bowel syndromeGastroenterology, 1995
- Basic and clinical aspects of visceral hyperalgesiaGastroenterology, 1994
- Reduction of rectal sensitivity and post‐prandial motility by granisetron, a 5 HT3‐receptor antagonist, in patients with irritable bowel syndromeAlimentary Pharmacology & Therapeutics, 1993
- Increased segmental activity and intraluminal pressures in the sigmoid colon of patients with the irritable bowel syndrome.Gut, 1989
- THE IRRITABLE BOWEL SYNDROME: A PAROXYSMAL MOTOR DISORDERThe Lancet, 1985
- Irritable bowel syndromeDigestive Diseases and Sciences, 1980
- Colonic Myoelectrical Activity in Irritable-Bowel SyndromeNew England Journal of Medicine, 1978
- Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndromeGut, 1973