Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
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Open Access
- 10 October 2002
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 347 (15), 1151-1160
- https://doi.org/10.1056/nejmoa021481
Abstract
The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and β-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human β-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis.Keywords
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