Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37°C and 42°C
- 31 August 2005
- journal article
- Published by Elsevier BV in Heart Rhythm
- Vol. 2 (8), 860-866
- https://doi.org/10.1016/j.hrthm.2005.04.029
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Drug-Induced Prolongation of the QT IntervalNew England Journal of Medicine, 2004
- Inherited Arrhythmogenic DiseasesCirculation Research, 2004
- Pharmacogenetic Considerations in Diseases of Cardiac Ion ChannelsThe Journal of pharmacology and experimental therapeutics, 2003
- [K+]o-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotypeCardiovascular Research, 2003
- Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de PointesThe Journal of pharmacology and experimental therapeutics, 2002
- Voltage Gating of Shaker K+ ChannelsThe Journal of general physiology, 1998
- A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivationThe Journal of Physiology, 1998
- A Review of Erythromycin-Induced Malignant Tachyarrhythmia— Torsade de PointesAngiology, 1997
- Cellular and Ionic Mechanisms Underlying Erythromycin-Induced Long QT Intervals and Torsade de PointesJournal of the American College of Cardiology, 1996
- Site-directed mutagenesis by overlap extension using the polymerase chain reactionGene, 1989