Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography
Open Access
- 27 July 2011
- journal article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 2 (8), 2392-2402
- https://doi.org/10.1364/boe.2.002392
Abstract
We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measured in 1 control eye and 3 eyes of trabeculectomy model rabbits. Polarization insensitive scattering OCT and the depth-resolved birefringence were measured simultaneously by PS-OCT. Abnormal birefringence was observed in keratoconus cases with advanced thinning and with a rupture of Descemet’s membrane. The graft-host interface of the keratoplasty case showed abnormal birefringence. The appearance of abnormal birefringence in the cornea was likely to be an indication of cross-linking of collagen fibrils. The measurement of rabbit showed abnormal birefringence in the scarring eyes. Wide regions of strong birefringence were observed in the eyes of trabeculectomy patients who had high intraocular pressure. Visualization of scarring in bleb by PS-OCT may be useful for the planning of secondary surgery. PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment.Keywords
This publication has 29 references indexed in Scilit:
- Performance of Automated Drusen Detection by Polarization-Sensitive Optical Coherence TomographyInvestigative Opthalmology & Visual Science, 2011
- Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulationOptics Express, 2010
- Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomographyJournal of Biomedical Optics, 2010
- Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomographyOptics Express, 2009
- Combinations of techniques in imaging the retina with high resolutionProgress in Retinal and Eye Research, 2008
- Imaging Polarimetry in Age-Related Macular DegenerationPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2008
- Three-dimensional Anterior Segment Optical Coherence Tomography of Filtering Blebs After TrabeculectomyJournal of Glaucoma, 2008
- Imaging of Birefringent Properties of Keratoconus Corneas by Polarization-Sensitive Optical Coherence TomographyPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2007
- Human Macula Investigated In Vivo with Polarization-Sensitive Optical Coherence TomographyPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2006
- Thickness and Birefringence of Healthy Retinal Nerve Fiber Layer Tissue Measured with Polarization-Sensitive Optical Coherence TomographyPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2004