Extremes of Age Are Associated with Indeterminate QuantiFERON-TB Gold Assay Results
Open Access
- 1 July 2014
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 52 (7), 2694-2697
- https://doi.org/10.1128/jcm.00814-14
Abstract
Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.0001) patients. A detailed analysis of indeterminate QFT-GIT assay results is presented.Keywords
This publication has 11 references indexed in Scilit:
- QuantiFERON®-TB Gold In-Tube Performance for Diagnosing Active Tuberculosis in Children and Adults in a High Burden SettingPLOS ONE, 2012
- Factors Associated with the Performance of a Blood-Based Interferon-γ Release Assay in Diagnosing TuberculosisPLOS ONE, 2012
- Immediate Incubation Reduces Indeterminate Results for QuantiFERON-TB Gold In-Tube AssayJournal of Clinical Microbiology, 2010
- Discordance between TSTs and IFN- release assays: the role of NTM and the relevance of mycobacterial sensitinsEuropean Respiratory Journal, 2010
- Comparison of interferon- release assays and tuberculin skin test in predicting active tuberculosis (TB) in children in the UK: a paediatric TB network studyArchives of Disease in Childhood, 2009
- The Likelihood of an Indeterminate Test Result from a Whole-Blood Interferon-γ Release Assay for the Diagnosis of Mycobacterium tuberculosis Infection in Children Correlates With Age and Immune StatusThe Pediatric Infectious Disease Journal, 2009
- Performance of Tests for Latent Tuberculosis in Different Groups of Immunocompromised PatientsChest, 2009
- Highly discordant T cell responses in individuals with recent exposure to household tuberculosisThorax, 2008
- Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patientsEuropean Respiratory Journal, 2007
- Specific immune-based diagnosis of tuberculosisThe Lancet, 2000