Endothelial Function in Patients With Migraine During the Interictal Period
- 12 July 2006
- journal article
- Published by Wiley in Headache: The Journal of Head and Face Pain
- Vol. 47 (1), 45-51
- https://doi.org/10.1111/j.1526-4610.2006.00532.x
Abstract
The aim of this study is to evaluate endothelial function in migraineurs subjects during the asymptomatic period. Migraine has been proposed as a risk factor for cerebrovascular events. The underlying mechanisms that relate these 2 pathologies are unknown. Nitric oxide (NO) has been proposed as the final causative molecule of migraine. Increased NO metabolites concentrations have been reported in migraineurs subjects during acute migraine attacks, but there is no evidence indicating alterations in endothelial NO release during the symptom free period in theses subjects. Fifty migraineurs subjects and 25 healthy subjects matched by gender and age were included. Every subject underwent a complete examination that included medical history, physical examination, resting electrocardiogram, forearm flow-mediated vasodilation (FMD), blood determinations of fasting nitrates and nitrites (NO(2) (-)+ NO(3) (-)), glucose, lipid profile, creatinine, C-reactive protein, and blood cell count. No differences in FMD or NO(2) (-)+ NO(3) (-) were detected among groups. The only difference between migraineurs and control subjects was a higher mean blood pressure 92.1 (8.8) mmHg versus 86.7 (8.2) mmHg P= .01. The endothelial function is not altered during the interictal period in migraineurs subjects.Keywords
This publication has 40 references indexed in Scilit:
- MRI findings in migraineRevue Neurologique, 2005
- Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA studyBrain, 2005
- Interaction between nitric oxide and the cholinergic and sympathetic nervous system in cardiovascular control in humansPharmacology & Therapeutics, 2005
- Use of the headache impact test (HIT‐6) in general practice: relationship with quality of life and severityEuropean Journal of Neurology, 2005
- Colombian Study to Assess the Use of Noninvasive Determination of the Endothelium-Mediated Vasodilation (CANDEV) II. Does Location of the Occlusion Device Affects the Accuracy of the Diagnosis?Endothelium, 2005
- Migraine and strokeNeurological Sciences, 2004
- Increased Plasma Nitrites in Migraine and Cluster Headache Patients in Interictal Period: Basal Hyperactivity of L-Arginine-No Pathway?Cephalalgia, 2002
- Headache and Cardiovascular Risk Factors: Positive Association With HypertensionHeadache: The Journal of Head and Face Pain, 1999
- L-arginine/nitric oxide pathway activation in platelets of migraine patients with and without auraActa Neurologica Scandinavica, 1996
- Evidence for Instability of the Autonomic Nervous System in Patients With Migraine HeadacheHeadache: The Journal of Head and Face Pain, 1992